• Circulatory Responses to Asphyxia Differ if the Asphyxia Occurs In Utero or Ex Utero in Near-Term Lambs 

      Sobotka, Kristina S.; Morley, Colin; Ong, Tracey; Polglase, Graeme R,; Aridas, James DS; Miller, Suzanne L; Schmölzer, Georg M.; Klingenberg, Claus; Moss, Timothy J.M; Jenkin, Graham; Hooper, Stuart B. (Journal article; Tidsskriftartikkel; Peer reviewed, 2014)
    • Efficacy of Intravenous, Endotracheal, or Nasal Adrenaline Administration During Resuscitation of Near-Term Asphyxiated Lambs 

      Songstad, Nils Thomas; Klingenberg, Claus; McGillick, Erin V.; Polglase, Graeme R.; Zahra, Valerie; Schmölzer, Georg M.; Davis, Peter G.; Hooper, Stuart B.; Crossley, Kelly J. (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-06-02)
      <i>Objectives</i>: Neonatal resuscitation guidelines recommend administering intravenous (IV) adrenaline if bradycardia persists despite adequate ventilation and chest compressions (CC). Rapid IV access is challenging, but little evidence exists for other routes of administration. We compared IV, endotracheal (ET), and intranasal routes for adrenaline administration during resuscitation of asphyxiated ...
    • Expired CO2 Levels Indicate Degree of Lung Aeration at Birth 

      Hooper, Stuart B.; Fouras, Andreas; Siew, Melissa; Wallace, Megan; Kitchen, Marcus; te Pas, Arjan B; Klingenberg, Claus; Lewis, Robert; Davis, Peter; Morley, Colin J.; Schmölzer, Georg M. (Journal article; Tidsskriftartikkel; Peer reviewed, 2013)
      As neonatal resuscitation critically depends upon lung aeration at birth, knowledge of the progression of this process is required to guide ongoing care. We investigated whether expired CO2 (ECO2) levels indicate the degree of lung aeration immediately after birth in two animal models and in preterm infants. Lambs were delivered by caesarean section and ventilated from birth. In lambs, ECO2 levels ...
    • Single sustained inflation followed by ventilation leads to rapid cardiorespiratory recovery but causes cerebral vascular leakage in asphyxiated near-term lambs 

      Sobotka, Kristina S.; Hooper, Stuart B.; Crossley, Kelly J.; Ong, Tracey; Schmölzer, Georg M.; Barton, Samantha K.; McDougall, Annie R.A.; Miller, Suzie L.; Tolcos, Mary; Klingenberg, Claus; Polglase, Graeme R. (Journal article; Tidsskriftartikkel; Peer reviewed, 2016)
      Background A sustained inflation (SI) rapidly restores cardiac function in asphyxic, bradycardic newborns but its effects on cerebral haemodynamics and brain injury are unknown. We determined the effect of different SI strategies on carotid blood flow (CaBF) and cerebral vascular integrity in asphyxiated near-term lambs. Methods Lambs were instrumented and delivered at 139 ± 2 d gestation ...